These properties are caused by the following effects:
- is interferonogenic.
The antipyretic effect of the drug is provided as a result of its effect on the thermoregulatory zones of the hypothalamus.
The presence of a pronounced anti-inflammatory reaction due to Amizon is due to stabilization of plasma membranes, delayed release of histamine from basophilic granulocytes, normalization of the basal level of prostaglandins, increased anaerobic and cerebral energy metabolism, and weakened vascular responses.
The regulatory effect of the drug on the immune system is manifested in the form of enhancing the humoral and cellular immune response of the body. From the biochemical point of view, this is reflected in the form of normalization of the level of lysozyme, the growth of antibody titers and endogenous interferons in the blood plasma, growth and increase in the functional activity of macrophages.
Analgesic effect is due to the effect of the drug on cholinergic formations of the reticular formation of the brainstem.
As an oral low-molecular inducer of interferon, this iodine-containing analgesic provides control over the processes of its synthesis by the immune system.
The specific therapeutic value of this drug is due to the lack of:
- nephrotoxic, allergic, embryotoxic, mutagenic, hepatotoxic properties;
- irritation of the mucous membranes of the stomach;
- has a negative effect on blood biochemistry.
During the oral administration, rapid absorption of the drug from the digestive tract( up to 65%) is ensured. The maximum concentration( Cmax) is observed after 2 hours. Amizon is excreted in the urine( 95%).The presence in the tissues of Amyzon metabolites is not determined after 3 hours, in the bloodstream - after 14 hours.
Indications for use Amizone
Amizon is prescribed for therapy and urgent non-specific prophylaxis:
- of viral-bacterial and bacterial infections of the respiratory tract, as well as ENT organs of severe course( angina, pneumonia, mononucleosis);
- infections against the background of immunodeficiency;
- varicella, measles, rubella, scarlet fever, mumps;
- skin-joint forms of erythema breaker, benign lymphoreticulosis.
The drug is also used in the complex therapy of patients with:
- hepatitis A, E and mixed infections( hepatitis A + E);
- with chronic brucellosis;
- with meningoencephalitis and meningitis of a bacterial or viral nature;
- by typhoid fever;
- by diseases caused by the herpes simplex virus, including adenoviral conjunctivitis, herpetic keratitis, uveitis, keratoconjunctivitis;
- osteochondrosis, herniated intervertebral discs, arthritis, neuralgia.
As an adjuvant Amizon is used to stop inflammatory processes in gynecological and surgical practice.
Instructions for Use
Amizone must be taken orally after meals without chewing.
During the clinical trials the following dose limits were established:
- maximum single dose - 1 g;
- diurnal - 2 g.
. If there are no specific recommendations, for therapeutic purposes, adult patients are assigned 2 to 4-time intake of 1-2 tablets per week;children of 6-12 years are recommended 2-3-time reception for ½ tablets( 0.125 g) for 5-7 days.
In order to implement measures aimed at the prevention of acute respiratory infections and influenza, Amizon should be taken in consideration of the following dosages:
- , adult patients are given a single dose of 1 tablet for 4-5 days, followed by a 2.5-3 week dose of 1 tablet every 2-3 days;
- patients of 12-16-year-old age are prescribed taking 1 tablet every two days for 2.5-3 weeks;
- for children 6-12 years of age, it is recommended to take ½ tablets every two days for 3 weeks.
In the therapeutic practice of treatment of meningoencephalitis, adult patients are prescribed a 3-time dose of 0.25 g for 10 days.
For the purpose of complex therapy and urgent nonspecific prophylaxis of viral hepatitis, it is recommended to take Amizon with the following dosages: adult patients are assigned a 3-time intake of 0.25 g for the first 5 days from the moment of the disease.
Within the framework of complex therapy of viral-bacterial and bacterial infections of the respiratory tract, a 3-time intake of 0.25 g for 12-15 days is prescribed. As an adjuvant, Amizon is used to relieve pain syndromes, while a 3-4-times intake of 0.25-0.5 g is recommended for two weeks.
Possible side effects of
In the indicated therapeutic dosages, the drug shows good tolerability, does not show nephrotoxic, allergic, embryotoxic, mutagenic, hepatotoxic properties. Individual patients may note the presence of mild edema of the mucous membranes and a feeling of bitterness. Such phenomena do not require special measures or the withdrawal of Amizon.
In case of an overdose of Amizone, side effects may occur. Adequate response in this case is the procedure for gastric lavage.
Contraindications to use
Do not take medication:
- for children under 6 years of age;
- for women in the first trimester of pregnancy;
- to persons who are hypersensitive to iodine preparations.
Features of drug interaction
When Amizon is taken, the effect of immunomodulating, antibacterial, antitoxic agents is greatly enhanced. Optimal and expedient, from a therapeutic point of view, is the combination of Amizon with high doses of vitamins, in particular, ascorbic acid. Justified is a complex therapy, in which Amizon is combined with interferon. In this case, children are recommended to assign an anti-influenza, as well as normal human leukocyte interferon, and to adult patients - human recombinant genetic engineering.
Form release and description of the package
The drug is sold through the pharmacy network in the following form:
- for 10 tablets in a cellular or non-celled package;
- for 5 contour packs in each carton pack.
Storage Requirements for
Keep Amizone out of the reach of children, dry, light-shielded places. Do not exceed the shelf life of the product indicated on the package.
Terms of delivery in the pharmacy network
Amizone is dispensed without a prescription.
Composition of the preparation
Each tablet contains 0.25 g of aminosone. As auxiliary substances used: calcium stearate, potato starch, low molecular weight polyvinylpyrrolidone.
Chemical formula: N-methyl-4-benzylcarbamidopyridinium iodide.
Description: flat tablets with chamfers and risks, yellow or light green.
Patients are strongly advised to consult a physician before performing therapy with Amizone. The given instruction is given with a view of acquaintance. More detailed information should be obtained in the annotation developed by the manufacturer.
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