- Basic requirements for drug therapy of varicose
- Group of phlebotonics
- Group of drugs that promote blood thinning
- Anti-inflammatory drugs
- Medicines for external use
Varicose illness causes many troubles to its "owners".Pain, swelling on the legs due to sagging veins, the inability to wear stylish shoes dramatically reduces mood, performance.
Existing surgical methods promise attractive results, but they are used mainly as paid services and not all are affordable. Yes, and the fear of the single word "operation" makes you go far around the clinic.
Therefore, the population is fond of folk methods of treatment, consults each other about the "miraculous" tablets.
Basic requirements for drug therapy for varicose veins
Effective treatment of extended veins on the legs is possible if the selected drug counteracts the mechanisms of disease development, the destruction of the venous wall and valves. The main directions of drug therapy:
- restoration of blood flow in the vessels of the lower limbs;
- strengthening of the vein wall, prevention of loss of elasticity;
- assisting the valve apparatus to prevent the return flow of blood in the vertical position of a person;
- increase in the tone of the muscles of the vessels and lower legs;
- ensuring the proper level of microcirculation in the capillaries of the feet and fingers;
- decrease in blood viscosity and ability to thrombogenesis;
- anti-inflammatory effect on the vascular wall and surrounding tissues.
The success of therapy depends on the stage of the disease, the use of drugs that can prevent serious complications( thrombophlebitis, embolism of vital vessels).The list of the most severe consequences of varicose veins is led by pulmonary embolism.
Medicines for the treatment of varicose veins differ in the mechanism of action, have their limitations and contraindications.
Group of phlebotonics
Phlebotonics or venotonicks are called agents that increase the tone of the venous wall by restoring the transmission of nerve impulses, enhancing the synthesis of hyaluronic acid in cells and increasing elasticity. They affect the contractility of the veins, increase the outflow from the toes, reduce swelling of the feet and legs. Patients taking drugs, note the appearance of lightness in walking, the removal of pain and nighttime convulsions.
Venotonics have a different composition, can be simultaneously applied inside in tablets, capsules and topically in ointments, if necessary in injections. Distinguish:
- preparations, prepared from herbal remedies based on flavonoids and saponins;
- derivatives of rutoside;
- combination of drugs, including not only venotonics, but also anticoagulant medications, painkillers, having anti-inflammatory effect;
- is a purely synthetic preparation.
Flavonoids are found in the most useful fruits and vegetables, close in effect to vitamin C
From natural flavonoids and saponins( plants with biological activity, glycosides), drugs such as Detralex, Escuzan, Diosmin, Herbionus Esculus, Venarus, Aescin, Vasocet. Vegetable raw materials include digitalis, ginseng root, licorice, fruits and leaves of chestnut, calendula. In addition to the tonic effect, they reduce blood coagulability, have a lymphotropic effect( they transfer the liquid part of the blood during stagnation in the lymphatic vessels) and in this way remove swelling on the legs.
The group of agents from rutozides include popular drugs for varicose veins: Troxevasin, Troxerutin, Venoruton. They are similar in composition to saponins, but they are distinguished by a high content of vitamin P. Therefore, they are suitable for a targeted effect on the muscular wall of the veins.
Combined preparations are obtained by artificial combination of natural and synthetic components. The group includes: Troxevasin Neo, Doppelgerz, Angionorm, Worm.
Fully synthetic venotonicks are created from tribenozide, calcium salts. They include: Tribenozid, Glivenol, Calcium Dobesilat.
The main representatives of phlebotonics include the following.
Detralex - manufacturer - laboratory "Servier Industries", France( analogues of the Russian market Venozol and Venarus are manufactured in VIS Ltd. and Obolensky FP).The tablets are covered with a protective film. The drug is included in the evidence base for the effectiveness of effects on veins in the amount of two tablets. Contraindicated with individual hypersensitivity.
Detralex is not recommended for children, pregnant and lactating women, because the effect has not been studied.
Flebodia 600 is also a French preparation of the firm "Innotera Shuzi", it reduces vascular permeability, has antioxidant effect.
Vasoket - German preparation of the company "Stragen / Weimer Pharma" is available in tablet form.
Antistax - manufactured by Boehringer Ingelheim, Germany, belongs to the bioflavonoids
Troxevasin , trade names Venoruton and Troxerutin. It is produced and supplied to the pharmaceutical market by Bulgaria, by Pharmkhim. Refers to semi-synthetic derivatives of routine. It is used in the treatment of varicose veins of legs in capsules, gel, in ampoules for injections.
Anaveneol - refers to combined agents. Produced by Zentiva in the Czech Republic in the form of coated tablets. It is able to enhance the action under the influence of antibiotics. To side effects leads to an overdose, possible bleeding, complaints of dizziness, nausea.
Venoruton is a Swiss preparation of Novartis from the group of rutozides, forms of tablets and gel are known, it is not contraindicated for pregnant women in the second and third trimesters.
Ginkor fort - produced by France, the firm "Bofur Ipsen" in capsules and gel. In the composition: extract of ginkgo biloba, troxerutin, heptaminol hydrochloride. It is allowed in the 2nd and 3rd trimesters of pregnancy, but it is contraindicated in thyrotoxicosis and in the treatment with monoamine oxidase inhibitors. Overdose can cause hypertension.
Escudane - an affordable Russian remedy in drops, is made on the basis of an extract of horse chestnut with the addition of vitamin B1.
Group of drugs that contribute to the dilution of blood
The density of blood is determined by the rheological properties, the concentration of the main biological components. Reduced blood flow leads to a risk of thrombosis. The degree of risk increases the viscosity of the blood. Therefore, treatment requires the use of drugs that prevent the adhesion of platelets. These include:
- Trental - in tablets and ampoules for intravenous drip, in addition to antiaggregant properties, it is able to improve microcirculation and tissue trophism.
- Kurantil - is known as a means of restoring blood circulation in cardiac ischemia, but the mechanism of action is effective even with a decrease in blood flow in the veins of the lower limbs. Prevents sores and blood clots.
- Aspirin and the entire group of drugs based on acetylsalicylic acid( Cardiomagnol, Tromb Ass) remain indispensable diluting prophylactic agents. New drugs are not accompanied by irritation of the stomach, because they are covered with a protective coating.
Tablets are coated with a protective coating, do not affect the stomach.
Topical preparations include Venolife and Lyoton gels. Contain heparin, used to rub into the skin above the superficial varicose veins, for compresses overnight. They help relieve tension and pain, reduce swelling.
A group of non-steroidal anti-inflammatory drugs helps to relieve the inflammatory response of surrounding tissues, prevent the beginning phlebitis of the veins. They are shown in severe pain syndrome.
- Diclofenac is given in tablets, injections or gel. In addition to the anti-inflammatory effect, it is known to prevent thrombosis.
- Indomethacin is also used in three forms, indicated for pain, swelling.
These drugs are indispensable in the postoperative period, when the affected veins are removed, but it is necessary to prevent tissue inflammation.
Medications for external use
For external use, creams, gels and ointments are used. When buying a drug in a drugstore, you need to take into account that the ointment has the greatest concentration of the active substance.
General contraindication - the presence of lesions on the skin.
To rub the ointment preparation it is necessary to move from bottom to top, you can not squeeze the superficial veins
. Usually they are administered twice a day. In the evening, you can apply a compress to the most painful place of the foot.
The following preparations are offered in the pharmacy network for external treatment of leg varicose.
Gel Venoruton - the active substance serves as an analogue of the routine. Passing through the skin to the vein, the drug has an antioxidant effect, reduces the permeability of the wall, reduces edema of surrounding tissues. The tone of the veins rises, and the pain is gradually eliminated. The drug is not recommended in the first trimester of pregnancy.
Venitan - is made in the form of a cream and gel from a horse chestnut extract. Acts as a local phlebotonics. Well tolerated.
Ginkor gel - is a combination of leaf extract of ginkgo biloba and routine. It is allowed for pregnant and lactating women. It removes inflammatory changes in tissues.
Heparin ointment - a component of heparin by reducing blood clotting prevents the formation of parietal thrombi in the enlarged veins. Contains anesthesin, therefore local anesthetic effect is manifested. Can not be used for trophic ulcers.
Ointment Vishnevskogo or "Liniment balsamic Vishnevsky" - is appointed in the case of complicated launched varicose veins with trophic ulcers. In the composition: tar, bismuth salt, castor oil, xeroform. It has a wound healing property, is an antiseptic.
Gel Aescin is a combination of Escin( from horse chestnut), Heparin and natural phospholipids. It is believed that the "filling" of phospholipids improves the permeability for acting drugs deep into the skin and muscles, and, accordingly, the efficacy is improved.
Hepatrombin - superior to the effectiveness of Heparin ointment, because the composition includes allantoin and dexpanthenol. These substances improve metabolic processes in tissues, increase access of heparin to venous vessels.
When treating varicose veins of the legs with medication, one should not expect a rapid effect. The right course of therapy is prescribed by a doctor. Some funds must be taken for 2 months and continue after the break.
The doctor can advise the required effective drug after determining the stage of varicose veins. Lack of effect and the appearance of complications( increased edema, pain) is an indication for a surgeon's consultation.