13Mar

Glutoxim - instructions for use, indications, contraindications, possible side effects

Form and formulation of

In accordance with the instructions Glutoxim is manufactured in the form of an injection solution of 0.5%, 1% and 3%.Ampoules with a drug have a ring or break point, in each - 1-2 ml of the drug.

Content 1 ml of 0.5% Glutoxim solution - 5 mg of active substance, 1 ml of 1% - 10 mg and in 1 ml of 3% Glutoxim - 30 mg. Along with the active substance, auxiliary components are included in the solution: acetic acid, sodium acetate, sterile water.

The solution is presented as a transparent liquid without a smell or with a weak aroma of acetic acid.

The packaging of the preparation is a cardboard box, each package contains 5-10 ampoules.

Principles of the pharmacological action of Glutoxime

Glutoxim performs a modulating effect on intracellular processes within thiol metabolism, which plays a major role in the regulation of metabolic and genetic processes in the human body. The product produces hematopoietic( hematopoietic), hepatoprotective( protecting the liver cells) and immunomodulating effect. Glutoxim has a high tropism for cells of the lymphoid tissue system and central immunity organs.

This drug is included in the group of natural metabolites, which causes aspects of its pharmacological effects. After injection( intramuscular, subcutaneous or intravenous) bioavailability of it exceeds 90%.

The highest concentration of Glutoxim in the blood is recorded 2-5 minutes after intravenous injection and 7-10 minutes after intramuscular injection.

The drug is mainly excreted by the kidneys.

Indications for use

May be prescribed by the attending physician when:

  • prophylaxis and treatment of secondary immunodeficiency( caused by chemical, radiation or infectious factors) to achieve reductive immunoreactivity of the body and stimulation performed by bone marrow hematopoiesis;
  • use of the drug in order to activate the resistance of the body to aggressive influences( radiation, intoxication, etc.);
  • chronic viral hepatitis( B, C, D) as a hepatoprotective drug;
  • chronic obstructive pulmonary disease, to enhance the therapeutic effect of hormonal and antibiotic therapy;
  • prophylaxis of postoperative complications, manifested in the form of inflammation;
  • complex therapy of tuberculosis( disseminated tuberculosis of all localizations, drug resistance of mycobacterium tuberculosis), and also for the prevention of emerging toxic complications after antituberculous therapy;
  • complex treatment of psoriasis in moderate to severe cases of the disease( with arthropathy, erythroderma).

Contraindications to use

The drug is contraindicated in case of hypersensitivity to the components contained in the preparation.

There were no clinical trials among patients, pregnant or in the lactational period, hence, the drug is a priori prohibited for use by these categories.

Side effects of

In rare cases with therapy with this drug, there may be an increase in temperature to subfebrile parameters( 37.1-37.5 ° C).According to reviews, the administration of Glutoxim may be accompanied by painful sensations at the injection site. In this case, the solution can be combined with 1-2 ml of 0.5% solution of novocaine.

According to numerous reviews, Glutoxim is rarely accompanied by listed side effects and is excellently tolerated by patients.

Instruction for use

The agent is injected subcutaneously, intramuscularly or intravenously.

In accordance with the instructions, Glutoxim for the prevention of complications after surgery, as well as to prevent the effects of aggressive factors is recommended for daily administration in a dose of 5-10 mg. Duration of treatment 2-4 weeks.

In the treatment of inflammatory diseases of the genitourinary system, lungs, allergic pathology, 5-40 mg are prescribed daily( the course contains 50-300 mg of the drug).Duration of treatment is 2-3 weeks.

Complex therapy of tuberculosis by means of Glutoxim is determined by 60 mg daily( 30 mg twice), duration of treatment is two months. When a specific( tuberculous) inflammation passes into the productive phase, Glutoxim is used in a dosage of 10-20 mg 2 times a day 3 times a week. Repeated course after taking this drug is possible only after 1-6 months.

For the treatment of psoriasis, the drug is taken daily( intramuscularly) at 10 mg for 15 days, then administered twice a week( for 5 weeks).In the treatment of uncomplicated forms of this disease, and daily injections of Glutoxim - 10 mg per day for 10 days.

Glutoxim can simultaneously be injected with other water-soluble drugs in the same syringe.

Special instructions

In accordance with the instruction, 0.9% solution of sodium chloride( saline) or 5% glucose solution is recommended to be used with Intravenous Glutoxim as a solvent for intravenous injections.

Video

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