Protein is an important component necessary for the functioning of the body. Different types of it are involved in all biochemical processes. They take part in immune protection and blood clotting, transfer to organs and tissues various substances( lipids, minerals, pigments, hormones, drugs), maintain a pH balance in the blood, keep the blood elements in suspension, provide its viscosity and fluidity.
All proteins contained in the blood and differing in properties, structure and purpose, were called "total protein".Serum contains globulins, as well as albumins. In addition, the plasma is still fibrinogen, so the total protein of the plasma is higher than the serum. The blood test allows you to determine both the total content and concentration of individual fractions. If the protein in the serum is increased, they say about hyperproteinemia.
At different ages its protein concentration norm:
- from 43 to 68 g / liter - for newborns;
- from 48 to 72 - for children under 1 year;
- from 51 to 75 - for children from 1 to 4 years;
- from 52 to 78 - for children from 5 to 7 years;
- from 58 to 78 - for children from 8 to 15;
- from 65 to 80 - for adults;
- from 62 to 81 - for people from 60 years.
At its general level, the degree of impairment of protein metabolism in the body is assessed. Determination of its concentration is necessary in the diagnosis of cancer, kidney and liver diseases, with severe burns, eating disorders. Increased protein indicates a violation in the body. For one reason, this can not be established, additional research is needed.
Reasons for an increase in
Hyperproteinemia can be absolute and relative.
Absolute increase of is a rather rare phenomenon. It is caused by the production of pathological proteins, enhanced immunoglobulin synthesis or intensive protein production during the acute period of the disease. In this case, the causes of the increased protein may be as follows:
- Chronic polyarthritis.
- Hodgkin's disease.
- Cirrhosis of the liver.
- Chronic hepatitis.
- Chronic and acute infectious diseases.
- Infection of the blood.
- Autoimmune diseases( sarcoidosis, lupus erythematosus, rheumatoid arthritis).
- A particularly high level of protein is observed with hemoblastosis paraproteinemic: Waldenstrom disease, myeloma, and others. Its concentration can reach about 120-160 g / liter.
Absolute hyperproteinemia is observed in many serious diseases, including infectious, oncological, autoimmune and other
. As for , the relative increase in protein is due to the fact that the blood becomes thicker due to dehydration of the body. The reasons for this condition can be as follows:
Elevated fibrinogen in the blood
- Intestinal obstruction.
- Diabetes is non-sugar.
- Severe burns.
- Severe injury.
- Acute bleeding.
- Profuse diarrhea.
- Severe vomiting.
- Generalized peritonitis.
- Enhanced sweat secretion.
- Diabetic ketoacidosis.
- Chronic nephritis.
The concentration of protein can also increase in healthy people. In these cases, it rises for a short while and quickly returns to normal. False hyperproteinemia is observed:
- when the vein of the tourniquet is applied to the forearm during blood sampling;
- at physical exertion;
- with a sharp rise from the bed, that is, changing the horizontal position to the vertical one.
The total protein in the biochemical analysis of blood has no special diagnostic value. Any deviation from the norm requires additional research. If a high level of total protein is found in the blood, you need to find out why this happened. In most cases, this is a signal about a malfunction in the body. As a rule, its high level can not be the norm. It is necessary to quickly register with a doctor for examination, diagnosis and treatment, since this condition can be dangerous to health and life.