Diagnosis of a disease such as rheumatoid arthritis is necessary in order to detect the disease in time and determine its severity. Since there is a risk of disability or even become disabled, do not delay the procedure.
There are two diagnostic methods: the test for rheumatoid factor( RF) and the analysis of antibodies to cyclic citrulline peptide( ACPC).The first one, due to its specificity, is not used so often, as it allows to diagnose some other joint diseases, and the second one allows in the overwhelming majority of cases to accurately identify rheumatoid arthritis and the level of its neglect.
Advantages of AADCP before RF
Despite the fact that the RF test was previously very popular and was used almost everywhere, the appearance of the analysis on the ATSPP made it possible to quickly minimize the frequency of its conduct. The fact is that the new technique allows to predict with greater accuracy the presence of prerequisites for the occurrence of inflammation in rheumatoid arthritis.
The analysis of venous blood is carried out in a special laboratory
The main advantages:
- In rheumatoid arthritis, the accuracy of the test for ACP is about 80-90%.
- With the disease, the specificity of diagnosis is 98%.
- If the body has antibodies to the CCP, the analysis will reveal them even a few months before the manifestation of the disease. Also, with the help of the study, it is possible to predict the development of nonspecific articular syndrome in a serious form of arthritis.
- The presence of an ATSP can also indicate an aggressive course of the disease.
General information on the
Antibodies to the cyclic citrulline peptide are a specific group of autoantibodies capable of identifying abnormal peptides. With rheumatoid arthritis, a certain autoimmune reaction is formed in the body, as a result of which autoantibodies appear, which make it possible to diagnose the disease.
In simpler terms, citrulline is a necessary product for metabolism, it does not participate in the process of protein synthesis. From a healthy organism, he simply appears on his own. With rheumatoid arthritis, the reverse process occurs: its enzyme composition varies qualitatively and quantitatively. Because of this, citrulline is embedded in the protein of the cartilaginous tissue of the joints. In response, the body begins to reject proteins with citrulline, resulting in the following reaction: the immune system begins to produce antibodies to the cyclic citrulline peptide, that is, ACPC.
What is the use of the
ACS analysis? This study helps in the following cases:
- Diagnosis of rheumatoid arthritis in the first stage - up to 6 months.
- Diagnostics in early terms - from 6 months to a year.
- Diagnosis of seronegative forms of the disease( negative RF).
- Differentiation of different forms of arthritis and other joint diseases.
- Assessment of the risk of joint deformity in patients at the initial stage and early stages.
Analysis of ACP
Analysis of rheumatoid arthritis is performed on an empty stomach, the last meal should be at least 8-12 hours before the test. Approximately for a day it is forbidden to use juices, coffee or tea( especially with sugar).A few hours before the test should avoid smoking.
The study on ACPP is as follows: the patient from the vein is withdrawn blood, after which it is sent to a centrifuge( for the production of serum).If the blood test is not performed immediately, then the sample taken can be stored for a week if a special temperature regime is observed( from + 2⁰C to + 8⁰C).Also it can be frozen and stored at a temperature of -200⁰C, however a repeated cycle of defrosting and freezing is strictly unacceptable. The very research is carried out in a test tube by scattering the laser beam in a liquid medium.
The specialist should perform blood sampling for analysis of
. The standard norm of ACPC in a healthy person is 3 U / ml. A more overvalued figure indicates the development of rheumatoid arthritis. Than this indicator is higher, the more inflammatory lesion of joints develops.
The value obtained in the analysis allows us to characterize the severity of the disease and develop the most effective therapy. However, even after the improvement of the patient's condition, this indicator in the blood will remain at a high level, therefore it can not be considered a pledge of successful treatment.
It is necessary to remember and know! The final interpretation of the results obtained and the installation of an accurate diagnosis is the prerogative of a rheumatologist.
This analysis is of unquestionable importance in the diagnosis of the disease in its early stages, since with rheumatoid arthritis the symptomatology does not appear immediately. In the event that a physician receives an overestimated score, an effective treatment can be immediately assigned and full control over the patient's condition can be made.
- Advantages of AADC before RF
- General information on analysis of
- What is the purpose of the analysis of ACDs
- Analysis of