Grandaxin is a tricyclic with an active component of tofisopam. Refers to the clinical group of daytime tranquilizers, is a benzodiazepine derivative. It shows anxiolytic activity, while it does not have a sedative, muscle relaxant, anticonvulsant effect. Eliminates psycho-vegetative disorders, has moderate stimulating activity. A special feature of the drug is its severe effect on the human digestive tract.
- 1 Operating principle
- 2 Indications reception Grandaxinum
- 3 Contraindications
- 4 Side effects
- 5 Overdose
- 6 Dosage
- 7 Interaction with other medicinal products
tablets for Grandaxinum not typical muscle relaxant action, so he allowedto the appointment to patients who have been diagnosed with myopathy and myasthenia gravis. Grandaxin, unlike the other benzodiazepine derivatives, does not increase the effect of alcohol and does not result in the appearance of psychophysical dependence and withdrawal syndrome, if the recommended doses and method of administration are observed.
After ingestion, a fast and almost complete absorption of the active substance from the digestive tract occurs. The maximum concentration of tofizopam in the blood plasma is noted for two hours, after which it decreases. The half-life of the drug from the body is 6-8 hours. It is excreted mainly by kidneys with urine, to a lesser degree with feces.
Indications for taking Grandaxin
Grandaxin is used when:
- Neuroses and neurosis-like disorders( conditions in which there is a decrease in mood, sleep disturbance, irritability, suspiciousness, anxiety, fatigue, headaches).
- major depressive disorder
- mental adaptation menopausal disorder, premenstrual syndrome
- alcohol withdrawal syndrome
- myasthenia, myopathy, neurogenic muscle atrophy and other disorders associated with secondary neurotic symptoms that should not be prescribed anxiolytics, exhibiting pronounced miorelaksiruyuschee activity.
Grandaxin is contraindicated for use by patients who are hypersensitive to the ingredients in the formulation. Do not prescribe medication to patients with conditions accompanied by anxiety of varying severity, aggressive behavior, depression.
In addition, contraindications to the prescription of the drug are respiratory failure in chronic form, the first trimester of pregnancy, lactation, apnea, galactosemia, congenital disruption of lactase production, acute respiratory failure arising from acute lesionslungs of different etiology, angle-closure glaucoma, epileptic seizures, organic brain damage( in particular, atherosclerosis).
It is not recommended simultaneous reception of Grandaxin with Tacrolimus, Sirolimus, Cyclosporin.
Most often, grandaxin has a negative effect on the digestive tract. In this case, there may be side effects in the form of lack of appetite, constipation, increased gas production, nausea, vomiting, dry mouth. Single cases of development of cholestatic jaundice have been documented in the presence of a tranquilizer.
Prolonged use of the drug may cause headaches, insomnia, increased irritability, psychomotor agitation, confusion symptoms, the development of epileptic seizures in patients with a history of epilepsy.
Also, grandaxin can trigger the development of allergic reactions in the form of rashes on the skin, itching, burning, redness. In this situation, it is necessary to cancel the drug and, possibly, its replacement with another drug with another active substance. There are data on the occurrence of side effects in patients taking tranquilizer in the form of respiratory depression, myalgia, muscle tension.
Treatment with grandaxin with the use of doses exceeding the recommended ones, can cause an overdose, manifested externally by the depression of the central nervous system. Overdose of drugs may indicate symptoms such as vomiting, symptoms of confusion, coma, respiratory depression and / or epileptic seizure.
First aid for the development of an overdose of a tranquilizer is to wash the stomach and take the sorbent. Artificially induce vomiting in the presence of symptoms indicating a marked suppression of the central nervous system, it is impossible.
When changing the basic physiological parameters of the patient should be symptomatic treatment. With respiratory depression, it is possible to carry out artificial ventilation of the lungs, drugs that stimulate the central nervous system should not be administered. With the development of hypotension, intravenous fluids can be injected and the patient transferred to Trendelenburg position. If there are no positive reactions to the above measures, the administration of Dopamine or Noradrenaline is recommended to restore normal blood pressure.
Dosage and method of application
- When prescribing a medicine, the patient's condition, clinical pathology and individual sensitivity to the components of the drug are taken into account.
- Adults appoint 1-2 tablets 1-3 times a day. Do not exceed the maximum daily dose, which is 6 tablets or 300 mg tofizopama.
- Patients who have impaired renal function, as well as elderly patients, are recommended to reduce the daily dose by about half.
Interaction with other drugs
It is not recommended to take Grandaxin concomitantly with preparations metabolized with the participation of the CYP3A4 isoenzyme, with drugs that suppress the functions of the CNS, inducers of hepatic enzymes, certain antifungal drugs( ketoconazole, itraconazole), certain antihypertensive drugs, beta-blockers, antacid agents, oral contraceptives.
Description of the mechanism of the action of Gramdaxin, see in the video:
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