Vilprafen: features of the drug

Vilprafen is an antibiotic( group of macrolides and azalides).The active substance is Josamycin. It is available in the form of 500 mg tablets. It is released by prescription.


  • 1 The active substance and excipients preparation
  • 2 Pharmacodynamics
  • 3 Pharmacokinetics
  • 4 Indications
  • 5 Contraindications
    • 5.1 Pregnancy and lactation
  • 6 Dosage
  • 7 Overdosing
  • 8 Side effects
  • 9 Nota Bene
  • 10 interaction with other drugs

The active substance and excipients preparation

Wilprafen Solutab. Packaging of the preparation

Vilprafen Soljutab. Packaging of the preparation


  • Microcrystalline cellulose;
  • Polysorbate;
  • Silicon dioxide;
  • Carmellose sodium;
  • Magnesium stearate.


The bactericidal effect of vilprafen( as well as all other macrolides) is due to a violation of protein production in the bacterial cell. The cell itself does not die, the bacteriostatic action is caused by a slowing of growth and the creation of obstacles for the further reproduction of bacteria. Wilprafen activity targets:

  • Gram-negative bacteria;
  • Gram-positive bacteria;
  • Intracellular microorganisms;
  • Anaerobic bacteria.

In regard to enterobacteria is ineffective, so after the course of treatment with Valfaren, there are no changes on the part of the digestive tract. With the patient's resistance to erythromycin and other macrolides, Valfaren retains its full activity. Josamycin is the drug of choice for a variety of different infectious diseases. For viral infections, it is prescribed only when the underlying disease is sensitive to Josamycin bacterial infections.


Absorption occurs in the gastrointestinal tract for 1-4 hours. It is distributed evenly in all groups of internal organs( with the exception of the brain).Plasma proteins bind about 15% of the substance. The highest content of Josamycin is found in the lungs, saliva, tonsils, and sweat. Sputum content is more than 8-10 times intraplasma. It is processed by the liver, excreted with bile. With urine, not more than 20% of the substance is released. Contained in breast milk, able to penetrate the fetus through the placental barrier.

Valfaren is recommended by WHO for the treatment of chlamydial infection in nursing mothers and pregnant women. In case of infection of a pregnant woman with sexually transmitted diseases, treatment with Josamycin is indicated, which is capable of simultaneously having a therapeutic effect both on the organism of the pregnant woman and on the fetus. Special cases: in liver diseases accompanied by impaired function, the Valfaren metabolism period may be prolonged. This should be taken into account to prevent a cumulative( accumulative) effect and an overdose.

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Indications for use of Vilprrafen:

  • Infectious diseases of the upper respiratory tract and ENT organs;
  • Diphtheria;
  • Scarlet fever;
  • Pneumonia, acute bronchitis;
  • Psittacosis;
  • Pertussis;
  • Dental infections;
  • Ophthalmic infections;
  • Wound infections;
  • Burn infections;
  • Venereal infections;
  • Dermatological infections.


  1. Intolerance to Josamycin and other macrolides;
  2. Children weighing up to 10 kg;
  3. Severe liver disease.

Pregnancy and lactation

The drug is taken during pregnancy and during the breastfeeding period.

Dosage of

Wilprafen. Form release - tablets

Wilprafen. Form release - tablets

The standard scheme of treatment involves taking 1-2 grams a day( 1 tablet 2-4 times).Dosage and duration of therapy is determined only by the attending physician and depends on the form and severity of the disease. The most frequently prescribed courses are from 5 to 20 days. Chronic tonsillitis is treated by courses not less than 10 days. The optimal mode of drug consumption is between meals.

Antibiotic treatment: josamycin( 1 g / 2 times a day) in combination with other drugs - famotidine or ranitidine + metronidazole, omeprazole, lansoprazole, pantoproprazole, esomeprazole, rameprazole + amoxylicin + trisalium bismuth + furazolidone * all drugs are usually prescribed in standard dosages. A specific treatment regimen can only be determined by the attending physician).Atrophy of the gastric mucosa: amoxicillin + Jozamycin + bismuth tricalcium.

Acne: 2-4 weeks to 1 ton / 2 times a day, then 1 ton / day for 2 months as a maintenance treatment. In case the patient missed taking the drug, you should immediately drink the medicine. Combine the next and missed receptions of the drug is not recommended.


There were no recorded cases of Wilprafen poisoning. With pronounced manifestations of side effects, specific symptomatic therapy is needed.

Side effects of

  • Allergic reactions are statistically rare;
  • Disturbances of the gastrointestinal tract and liver;
  • Rarely, hearing impairment, purpura.
  • Contraindications
  • Severe liver pathology;
  • Children whose body weight did not reach 10 kg;
  • Hypersensitivity to any drug from the macrolide group;
  • Intolerance to vilprafen.
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Nota Bene

Wilprafen Solutab - antibiotic

Vilprafen Solutab - antibiotic

In case of severe persistent diarrhea, you can expect the development of pseudomembranous colitis, which can threaten not only the health, but also the life of the patient. The dose of Jozamycin should be discontinued immediately and take all the necessary therapeutic actions to restore the normal function of the digestive tract. With renal failure during the therapy with macrolides, constant monitoring of the level of creatinine clearance is necessary.

Some microorganisms may have cross-resistance to macrolides( with the resistance of bacteria to a single drug from this group, one can expect that Josamycin will also prove to be ineffective).Does not affect the ability to manage complex machinery and vehicles.
In severe hepatic pathologies, the drug is contraindicated.

Interaction with other

  • Antibiotics. With the joint appointment of Josamycin with other antibacterial drugs, their therapeutic effect can be reduced( especially - penicillins and cephalosporins).Simultaneous reception of Vilprafen and Linkomycin depresses the therapeutic effect of both drugs.
  • Xanthines. All macrolides inhibit the process of isolation of theophylline. This, in turn, can lead to intoxication. In Vilprafen this effect is expressed in less than in other drugs from the group of macrolides.
  • Antihistamines. All drugs from the macrolide group and Wilprafen, in particular, have a depressing effect on the process of isolating antihistamines( especially those containing astemizole, terfenadine), which can lead to the development of irregular heartbeat rhythm.
    Alkoloids of ergot. Several separate cases of vasoconstriction enhancement with simultaneous administration of Vilprrafen and ergot alkaloids have been documented.
  • Cyclosporine. When combined, there may be an increase in the concentration of cyclosporine in the plasma, which increases the risk of nephrotoxicity.
  • Digoxin. Simultaneous application may increase the serum digoxin content.

Among modern medicines used to treat various infections of virtually all organs and systems of the body( except for infectious diseases of the brain), Vilprafen showed very high efficiency. Considering the group of macrolides, even among these antibiotics, Josamycin has a high degree of impact on the infectious environment.

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