Wilprafen - a drug for the control of Helicobacter pylori and not only

Vilprafen is an antibiotic belonging to the macrolide group. For the purchase of tablets, a doctor's prescription is required. For storing the medicine, places that are protected from light and not accessible to children, with a temperature regime not exceeding 250 ° C, are suitable. The tablets are suitable for use for 4 years.


  • 1 issuance
  • 2 Pharmacological action
  • 3 Pharmacokinetics
  • 4 Drug Interactions
  • 5 Dosage and overdose
  • 6 Side effects
    • 6.1 Vilprafen during pregnancy and lactation period
  • 7 Indications
  • 8 Contraindications
  • 9 Cautions


Vilprafen issuance to combat Helicobacter

pylori OnBoth sides of oblong biconvex tablets, enclosed in a film shell of white hues, are marked with risks. In the blisters stacked in cardboard packages, there are 10 tablets. The active substance in the medication is josamycin.

Pharmacological action of

An antibiotic is indicated for impaired protein synthesis that occurs in microbial cells. Due to the adjusted therapeutic concentrations, a bacteriostatic effect is achieved, leading to a slow development of pathogens. Bactericidal efficacy is achieved by ensuring in the foci of inflammation the limiting concentration of josamycin.

Wilprafen does not allow the development of Gram-positive and Gram-negative bacteria. With regard to enterobacteria, he is powerless, therefore practically does not break the microflora of the gastrointestinal tract.


Suction process. Wilprafen is a rapidly absorbed agent. Food does not affect the bioavailability of the antibiotic. The maximum concentration of josamycin in plasma is noted an hour after ingestion.
Distribution process. Plasma proteins bind up to 15% of the active substance. An excellent dispersal of the drug by the tissues is noted( which does not apply to the brain).In this case, a concentration appears in them, which exceeds that observed in the plasma.

This saturation contributes to the preservation of a long-term therapeutic effect. Josamycin in the maximum concentrations found in the study of the lungs, tonsils, saliva, sweat and tear fluid. Sputum is saturated with it 8 times more plasma.

Wilprafen is found in breast milk. Overcoming the placental barrier for the remedy is not a problem.

The process of metabolism. The liver is the site of the metabolism of josamycin. It is here that the substance is split into metabolites with less activity. The process of excretion - up to 10% of the medicament is removed by the kidneys, the rest comes out with a flow of bile.

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Drug interaction


Wilprafen. Form release - tablets

Simultaneously taking bacteriostatic and bactericidal antibiotics, reduce the antibacterial effectiveness of the latter, so they do not resort to joint use. Josamycin and lincosamides have a reciprocity that reduces the therapeutic effects of each other.

Some antibiotics similar to Vilprafen prevent the removal of xanthines, which provokes intoxication. However, the process of withdrawal of theophylline does not slow down in the presence of this drug.

At the same time, using josamycin with antihistamine medicines, including terfenadine or astemizole, notice a delayed removal of the latter and the occurrence of arrhythmias that threaten life.
An episode of vasoconstriction caused by the combination of vilprafen and ergot alkaloids was recorded.

The combination of josamycin and cyclosporine leads to an elevated level in the blood of the latter, which sometimes results in nephrotoxicity. Therefore, there is constant control over plasma saturation with cyclosporin.

Combining the administration of josamycin and digoxin, the risk of an increase in serum levels of the latter.

Dosage and overdose

The official instructions for use of Vilprafen contain a description of the daily doses recommended for use. Adults and adolescents are prescribed 1-2 g, which need to be divided between 2-3 doses( the standard dosage is 500 mg 3 times / day).Special cases require an increase in the dose to 3 g / day.
The timing of the appointment is determined by the doctor. He, having established the nature of the infection and the severity of its course, appoints Wilprafen for 5-21 days.

So, with streptococcal tonsillitis, the drug takes at least 10 days. Until the typical symptoms of an overdose of Wilprafen have been noted. Presumably, an overdose of this agent may cause or exacerbate existing side effects associated with the gastrointestinal tract.

Side effects of


Wilprafen Solutab. Form release - tablets

Side effect of taking an antibiotic is associated with discomfort in the gastrointestinal tract, nausea, vomiting, diarrhea, constipation, decreased appetite, pseudomembranous colitis, stomatitis, hepatic dysfunction, jaundice. Purple is extremely rare. Sometimes its use results in allergies, hives, Quincke's edema, anaphylactoid reaction, bullous dermatitis, multiforme exudative erythema. Hearing disorders, noted infrequently, are described as dose-dependent and transient.

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Vilprafen during pregnancy and during the lactation period

This antibiotic is allowed to treat pregnant and lactating women. However, prior to the appointment, a medical evaluation involving a benefit / risk is necessary. The drug is recommended to suppress chlamydial infection that affects pregnant women.


Apply Vilprrafen in infectious and inflammatory diseases, provoked by drug-sensitive microorganisms. It is designed to suppress:

  • Infections developing in the respiratory tract and ENT organs( bronchitis, pneumonia, pharyngitis, tonsillitis and other diseases).
  • Diphtheria( in combination with diphtheria antitoxin).
  • Scarlatins( when hypersensitivity is detected with respect to penicillin).
  • Pertussis and psittacosis.
  • Dental infections( gingivitis, alveolitis, alveolar abscess, pericoronitis, periodontitis and others).
  • Ophthalmic infections: blepharitis, dacryocystitis.
  • Infections formed on the skin and soft tissues( folliculitis and furuncles, furunculosis, lymphangitis and lymphadenitis, phlegmon, panaritium and erysipelas, acne and abscesses).
  • Wound( including postoperative) and burn infections.
  • Infections of the genitourinary system( urethritis, cervicitis, epididymitis, prostatitis caused by chlamydia and mycoplasmas).
  • Gonorrhea, syphilis and venereal lymphogranuloma.
  • Diseases of the gastrointestinal tract, provoked by Helicobacter pylori( ulcers and gastritis).



Wilprafen. Group - antibiotics

Vilprafen is not prescribed with aggravated functional liver disorders, hypersensitivity to antibiotics related to macrolides, josamycin and accessory ingredients of the medication. They do not cure children, whose weight is less than 10 kg.

Special instructions

Stably severe diarrhea with Wilprafen therapy sometimes turns into life-threatening pseudomembranous colitis. Renal failure during the therapy forces us to rely on the results of the tests. They focus on the cross-resistance to antibiotics related to macrolides. Pathogens are able to show resistance to related antibiotics, which have a similar chemical structure. They may well prove to be resistant to josamycin.

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