19Feb

Eternal youth. .. Is rapamycin capable of this?

rapamycin

Rapamycin is an immensely popular immunosuppressive drug that takes a significant place in transplantology. Researchers claim that it is he who can become that desired elixir of youth and an extract of a long life.
For the first time, the chemical combination of rapamycin became known in the 70s of the last century, when it was found in soil samples on Easter Island. In 2009, thanks to the efforts of American scientists, the influence of the substance on the life of rodents was discovered. It turns out that it allows you to live 15% longer. However, it was discovered that rapamycin also increases the risk of diabetes.

Contents:

  • Advantages and disadvantages: work on bugs!
  • Food and life expectancy

Advantages and disadvantages: work on bugs!

In modern medicine, rapamycin serves as an immunosuppressant designed to prevent the rejection of a donor organ. At the same time, scientists continue their hard work aimed at preserving its life extension properties and eliminating possible side effects. Finally, all attempts were successful: in March, Science published an article that showed that American biologists were able to find the secret of the substance. Employees of the University of Pennsylvania and the Whitehead Institute found that in the human body, the rapamycin drug interacts with two proteins, MTORC1 and MTORC2.It is interesting that his influence on the first protein is reflected in the prolongation of life, and on the second - gives rise to diabetes."If we can create such a drug that reacts only with the first protein( MTORC1), then we will eliminate all the side effects," explains researcher Dr. David Sabatini.

Rapamycin became the central part of the experiments, as it was previously established that a decrease in TOR activity in some model animals( eg, roundworms or flies) increases the average life expectancy.

For mice, they started to inject rapamycin when they have already entered the elderly age of 600 days. This indicator corresponds to the human 60-year-old age. It is noteworthy that such a course of research was completely unplanned. Simply in all three institutes, where the experimental mice were born, there were some technical difficulties with the supply of rapamycin in the food. It was found that a mixture of mouse feed destroys this substance too quickly. Therefore, it took time to develop the technology of packaging the drug into special mini-capsules. And when everything was ready, the mice entered their old age. Thus, this technical problem helped to find more overwhelming results. Since the slowing down of aging in the later stages of life is an even more unthinkable problem than the impact on the young animal organism.

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Food and life expectancy

Today, researchers know only one way of prolonging life - reducing the number of products consumed. This mechanism is explained by the interaction of the protein MTORC1 and rapamycin. Experiments on rodents have repeatedly shown that if you reduce the total number of calories by 30%, then the prescribed norms of nutrition require, then the life expectancy significantly increases. Unfortunately, such studies are valuable so far only in theory. The invention of effective "drugs of eternal youth" is still only a phantom desire. Rapamycin is characterized by a large number of side effects, which excludes the possibility of people taking it.

The authors of the discovery caution that the substance should be used with great care, as it inhibits the activity of the immune system( therefore, prescribing drugs only on the basis of rapamycin to patients who underwent donor operations).

But let's not despair, perhaps rapamycin is the first step towards the desired result? Dreaming, do not forget that the life expectancy of a person is affected by the quality of his nutrition. But this is 100% proven! Well, about the other "elixirs of eternal youth" will tell the video:

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